Freitag, 3. August 2018

New features in skyline - LC-IMS-CID-MS and contaminations library


There is a lot going on in the skyline world lately. Originally, open source software skyline from the MacCoss Lab which started out as analysis tool for label-free quantification and MRM analysis of MS data.
Over years a lot of features have been added because more comprehensive analysis was requested by the users or new instruments using new scan modes have been introduced to the market. That's why recently ion mobility functionality has been added, including the entire LC-IMS-CID-MS workflow.


However, yet another skyline feature caught my attention in the current JASMS. A contamination library has been integrated into skyline. It contains over 684 common MS contaminations, which can be used as an transition list for MS1 filtering and is also provides a approach to determine unknown contaminations via a mass-to-formula tool. The mentioned transition list can be downloaded in the public repository panorama.


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