Breaking the 10000 Protein Group IDs for mammalian cells

This worth noticing and really a milestone in proteomics -
nanoLC-MS is complex method it combines the orthogonality of an nanoflow LC and an cuting edge MS, which either acquires and fragments bottom up peptide ions in parallel or superfast (i.e. a beam type instrument). During the years MS vendors and research groups came up with innovative acquisition modii pushing the border of the maximum protein identification.
Investigators of the MPI Munich have developed a new aquisition mode, called BoxCar Acquistion which let them identify over 10000 protein group IDs in mouse cells and 6200 protein IDs in human cell.

As far as I understood BoxCar Acquistion optimized the MS1 precursor sampling by filtering only decidated m/z ranges by the quadrupole, injecting and storing them into the C-trap. The advantage here is that ions, which wont be visible within an full scan are now observed with sufficient S/N. The S/N can be controlled by the injection time of m/z mass ranges of interest.

Since this is a beautiful new tool in the hands of mass spectrometrist therefore it is deserved to be published in Nature.
https://www.nature.com/articles/s41592-018-0003-5