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Documentary about proteomics

I have watched this current documentary about proteomics last weekend. Some of the major players in the field contributed in this. It is made for a broader audience to gain an understanding about the proteomics and challenges scienists currently facing.

Really interesting was the inside view into the Beijing Proteome Research Center (BPRC) and its organization. "...ground floor with mass spectrometers, 2nd floor with molecular biology lab, 3rd floor accommodates the bioinformatics group and on the top floor a super computer is located. Why would one harbor a supercomputer on the top floor?

https://www.youtube.com/watch?time_continue=619&v=8m2_Rs-MaZA
Its worth watching!

Great stereochemistry tutorial

Back in the days I hated lectures about stereochemistry, but this tutorial, which I came across recently is definitly going to change this. Its well structured and I really like the 3D Jmol images.

Beautifully done Miss Burrmann.
http://www.chemeddl.org/resources/stereochem/

Breaking the 10000 Protein Group IDs for mammalian cells

This worth noticing and really a milestone in proteomics -
nanoLC-MS is complex method it combines the orthogonality of an nanoflow LC and an cuting edge MS, which either acquires and fragments bottom up peptide ions in parallel or superfast (i.e. a beam type instrument). During the years MS vendors and research groups came up with innovative acquisition modii pushing the border of the maximum protein identification.
Investigators of the MPI Munich have developed a new aquisition mode, called BoxCar Acquistion which let them identify over 10000 protein group IDs in mouse cells and 6200 protein IDs in human cell.

As far as I understood BoxCar Acquistion optimized the MS1 precursor sampling by filtering only decidated m/z ranges by the quadrupole, injecting and storing them into the C-trap. The advantage here is that ions, which wont be visible within an full scan are now observed with sufficient S/N. The S/N can be controlled by the injection time of m/z mass ranges of interest.

Since this is a beautiful new tool in the hands of mass spectrometrist therefore it is deserved to be published in Nature.
https://www.nature.com/articles/s41592-018-0003-5